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M94A3141.TXT
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1994-10-25
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Document 3141
DOCN M94A3141
TI Natural history of HIV infection in infected Haitians with known date of
seroconversion.
DT 9412
AU Deschamps MM; Pape JW; Johnson WD Jr
SO Int Conf AIDS. 1994 Aug 7-12;10(1):144 (abstract no. PB0002). Unique
Identifier : AIDSLINE ICA10/94369434
AB OBJECTIVE: To determine the Natural history of HIV infection in
seropositive heterosexuals with known date of seroconversion. METHODS:
From 1987-1993, 19 individuals from 475 discordant couples
seroconverted, based on CDC definition. Date of HIV seroconversion is
midpoint between last HIV (-) and first HIV (+). They were evaluated
clinically every 3 months with CD4 count every 6 months. The following
endpoints were: 1. Development of symptomatic conditions (CDC definition
category A and B). 2. AIDS. 3. Death. RESULTS: After a median follow-up
period of 32 months 4/19 became symptomatic. The symptom-free period was
15 months. Initial manifestations were: generalized lymphadenopathy in
3, Herpes zoster in 1; 2/19 developed AIDS at a mean of 48 months (AIDS
Latency period). The time period from seroconversion to death is 76
months with an AIDS survival time of 28 months. Fifteen seroconverters
remained free of symptom after a median follow-up time of 30 months:
with CD4 count > 500 in 11 individuals, and < 475 in 4 individuals.
CONCLUSION: After a median period of 32 months, 4/19 seroconverters
became sick, 2/19 developed AIDS and died; the remainders are free of
symptoms. This study in on-going and will be updated.
DE Acquired Immunodeficiency Syndrome/MORTALITY/*PHYSIOPATHOLOGY
AIDS-Related Opportunistic Infections/PHYSIOPATHOLOGY Female Follow-Up
Studies Haiti Herpes Zoster/COMPLICATIONS Human HIV
Infections/*PHYSIOPATHOLOGY HIV
Seropositivity/MORTALITY/*PHYSIOPATHOLOGY Male Sex Behavior Time
Factors T4 Lymphocytes/IMMUNOLOGY MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).